Serum neurofilament light chain in progressive supranuclear palsy
نویسندگان
چکیده
منابع مشابه
Plasma neurofilament light chain predicts progression in progressive supranuclear palsy
OBJECTIVE Blood-based biomarkers for neurodegenerative conditions could improve diagnosis and treatment development. Neurofilament light chain (NfL), a marker of axonal injury, is elevated in cerebrospinal fluid (CSF) of patients with progressive supranuclear palsy (PSP). The goal of this study was to determine the diagnostic and prognostic value of plasma NfL in patients with PSP. METHODS Pl...
متن کاملFamilial progressive supranuclear palsy.
A progressive extrapyramidal syndrome and dementia occurred in three members of one family. The age of onset was in the seventh decade and the affected individuals showed many of the clinical features of progressive supranuclear palsy (PSP). Necropsy of one individual revealed the neuropathological features of PSP. We propose that this family has a familial form of PSP and review the evidence i...
متن کاملProgressive Supranuclear Palsy (PSP)
Introduction: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder producing characteristic eye movement abnormalities in the classic presentation. The disease pathologically is marked by accumulation of abnormal tau proteins. There are useful MRI features, however the diagnosis remains clinical in the majority of cases, and no objective diagnostic test exists. Treatment at...
متن کاملProgressive supranuclear palsy.
This review concentrates on the molecular pathology of the protein tau, including its expression in various regions of the brain. The role of post-translational modifications in fibrillogenesis is also discussed, particularly hyperphosphorylation and glycation. However, the initiating event that causes aberrant tau processing remains unclear.
متن کاملProgressive supranuclear palsy
Handbook of Atypical Parkinsonism, eds. Carlo Colosimo, David E. Riley, and Gregor K. Wenning. Published by Cambridge University Press. © Cambridge University Press 2011. Historical review Although the earlier literature contained several accounts of progressive supranuclear palsy (PSP) [ 1 ], including the famous case reported by Charcot in the nineteenth century [ 2 ], the fi rst detailed des...
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ژورنال
عنوان ژورنال: Parkinsonism & Related Disorders
سال: 2018
ISSN: 1353-8020
DOI: 10.1016/j.parkreldis.2018.06.018